@REI-AliciaS First class or Biz class flat-bed seat if you can get it.
But seriously, in coach, try the following:
Pick a seat far away from others if possible. If there are empty rows, even better: spreading out across more than one seat can make a big difference.
Some spots on the plane, especially around the exit doors, can get pretty cold—make sure a blanket is provided or bring your own light travel blanket.
Many long-haul planes have adjustable “wings” on the headrest that take the place of a neck pillow for me. YMMV, so bring something to support your head from flailing side-to-side.
Bulkhead rows on large planes usually have bassinets for people traveling with infants—not all babies will sleep through the flight... Avoid those areas if that will keep you up.
Ear plugs and eye shades are must.
Disposable slippers (the cheap ones you sometimes find in hotels) are great for when you get out of your seat. You can just leave them behind when you exit. Do NOT go into the lavatory barefoot or in your socks—that is not water on the floor!
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