@Cy one of the awesome things about cycling is you can change a lot of things on your bike to set it up the way that you want it. In order to best talk about options I need to ask some qualifying questions. Do you already have a particular bike in mind? If so what specific parts do you want to change (ie going to a 1x in the front? or changing the 'level' of the drivetrain) There are a lot of options but with so many different standards there is no simple answer. In helping customers in the past I would always recommend getting the bike that comes the closest to the setup that you want, you will have fewer parts to change and usually comes out as the most economical way to do it.
Ride safe out there!