I would consider a low shoe for myself, but only on even terrain that's reasonably dry. With a full pack and uneven or slippery terrain, I'll wear my mid-height waterproof boots, laced tight at the ankles, for the protection and support.
I hiked in the backcountry at Capitol Reef NP where trails can be poorly defined, rocky, with cross-slopes and plenty of chances to roll ankles. I was carrying 35# and my ankles were fine.
My trekking poles were valuable in giving me extra support to improve my footing on the worst parts.